Murray was trying to reach the last 16 in a slam for the first time since his hip problems began in 2017 but, after threatening another vintage comeback, fell to a 6-4 6-4 6 loss. -7 (1) 6-3 over Arthur Ashe Stadium.
The Scot is at least moving up the rankings and is set to reach his highest mark since May 2018 at around 43, but his ambitions remain much bigger than that and this is another season where he has been unable to get a place on the biggest stage.
Murray had spoken positively about his fitness and movement after dropping just one set in his opening two matches to advance to the third round in New York for the first time since 2016.
It was still a real step forward. Berrettini has struggled with injury and illness himself this year, but he has proven himself especially in the Slams.
He had reached at least the quarter-finals in the last four major tournaments he played, although he missed the French Open this year following a hand operation, then Wimbledon, where he reached the final last summer, after an ill-timed bout of Covid. -19.
Later that night, Draper’s fine run at the US Open ended in disappointment when he pulled out injured in the third set of his third-round clash with Karen Khachanov.
The 20-year-old picked up the biggest win of his career in the second round, beating sixth seed Felix Auger-Aliassime, and was well placed against Russia’s 27th seed Khachanov after recovering from a start slow.
But Draper started showing discomfort early in the third set and after losing serve in the 11th game and consulting with the coach called it a day down 6-3 4-6 6-5.